MYELOID NEOPLASIA Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome
نویسندگان
چکیده
1Division of Immune Cell Biology, Medical Research Council National Institute for Medical Research, London, United Kingdom; 2Children’s Hospital, Boston, MA; 3Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, United Kingdom; 4Institute of Cell and Molecular Science, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, London, United Kingdom; and 5Department of Haematology, Imperial College London, London, United Kingdom
منابع مشابه
Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome.
Trisomy of human chromosome 21 (Hsa21) results in Down syndrome (DS), a disorder that affects many aspects of physiology, including hematopoiesis. DS children have greatly increased rates of acute lymphoblastic leukemia and acute megakaryoblastic leukemia (AMKL); DS newborns present with transient myeloproliferative disorder (TMD), a preleukemic form of AMKL. TMD and DS-AMKL almost always carry...
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